A Conserved Interaction between the Replicative Clamp Loader and DNA Ligase in Eukaryotes
نویسندگان
چکیده
From the ‡Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center, San Antonio, Texas 78245, Molecular and Cellular Biology Graduate Program, University of Maryland School of Medicine, Baltimore, Maryland 21201, the ‡‡Program in Molecular Biology, Sloan Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, and the §§Radiation Oncology Research Laboratory, Department of Radiation Oncology and Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland 21201
منابع مشابه
A conserved interaction between the replicative clamp loader and DNA ligase in eukaryotes: implications for Okazaki fragment joining.
The recruitment of DNA ligase I to replication foci and the efficient joining of Okazaki fragments is dependent on the interaction between DNA ligase I and proliferating cell nuclear antigen (PCNA). Although the PCNA sliding clamp tethers DNA ligase I to nicked duplex DNA circles, the interaction does not enhance DNA joining. This suggests that other factors may be involved in the joining of Ok...
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